Diuretic action of garlic extract in anaesthetised normotensive dogs.

Intravenous administration of garlic extract (25.9 mg/kg body weight), significantly increases urinary output in dogs, whjch was also found to be dose dependent. The pH of urine was not altered after the administration of garlic extract. Effect of intravenous administration of Furosemide (1.0 mg/kg b. wt.) was also observed for control comparison. It was found that the garlic in high doses (54.0 mg/kg b. wt.) produces almost the same amount of increase in urinary out-put as does furosemide 1.0 mg/kg b. wt. It may be concluded that garlic produces its hypotensive action partially due to its diuretic effect(JPMA 36:280, 1986).